Significance (30 points) |
Does the project address an important problem or a critical barrier to progress in the field? If the aims of the project are achieved, how will scientific knowledge, technical capability, and/or clinical practice be improved? How will successful completion of the aims change the concepts, methods, technologies, treatments, services, or preventative interventions that drive this field? Is the proposal significant enough to generate future extra mural funding? |
Narrative c. The problem to be studied and its significance d. A brief review of the literature e. The methodology g. Plans for external funding |
__/30 |
Innovation (10 points) |
Does the application challenge and seek to shift current research or clinical practice paradigms by utilizing novel theoretical concepts, approaches or methodologies, instrumentation, or interventions? Are the concepts, approaches or methodologies, instrumentation, or interventions novel to one field of research or novel in a broad sense? Is a refinement, improvement, or new application of theoretical concepts, approaches or methodologies, instrumentation, or interventions proposed? |
Narrative c. The problem to be studied and its significance d. A brief review of the literature e. The methodology |
__ /10 |
Approach (30 points) |
Are the overall strategy, methodology, and analyses well- reasoned and appropriate to accomplish the specific aims of the project? Are potential problems, alternative strategies, and benchmarks for success presented? If the project is in the early stages of development, will the strategy establish feasibility, and will particularly risky aspects be managed? If the project involves clinical research, are the plans for 1) protection of human subjects from research risks, and 2) inclusion of minorities and members of both sexes/genders, as well as the inclusion of children, justified in terms of the research strategy proposed? |
Narrative c. The problem to be studied and its significance e. The methodology f. The timeline |
__/30 |
Investigator(s) (10 points) |
Is the Pl well suited to the project? If there are multiple Pl's in the early stages of independent careers, do they have appropriate experience and training? If more established, have they demonstrated an ongoing record of accomplishments that have advanced their field(s)? If the project is collaborative or multi-Pl, do the investigators have complementary and integrated expertise; is their leadership approach, governance and organizational structure appropriate for the project? |
Narrative k. Biosketch of applicant(s) |
__ /10 |
Environment (10 points) |
Will the scientific environment where the work will be done contribute to the probability of success? Are institutional support, equipment and other physical resources available to the investigators adequate for the project proposed? Will the project benefit from unique features of the scientific environment, subject populations, or collaborative arrangements? |
Narrative l. Support letters |
__ /10 |
Budget (10 points) |
Does the budget fall within the maximum limits for the award? Is each item justified for the proposed project? |
Narrative i. Budget |
__ /10 |