Dr. David Waddell
Molecular, cellular and genetic mechanisms of skeletal muscle atrophy
Grants reviews:
Dr. Waddell, Associate Professor from the Biomedical
Sciences Program in the Biology Department has recently participated in the
following study sections and grant reviews in the US, UK and Singapore
(2017-current):
Musculoskeletal, Oral, and
Skin Sciences AREA Study Section (R15) ZRG1 MOSS D82 for NIH on February 16,
2017.
Medical Research Council (MRC), United
Kingdom
Research and Innovation
, August, 2017.
National Research Foundation (NRF)
Competitive
Research Programme (CRP),
Prime
Ministers Office of Singapore, December, 2018.
National Centre of the Replacement,
Refinement and Reduction of
Animals in Research (NC3Rs), United
Kingdom Research and Innovation,
May, 2018.
Biotechnology and Biological Sciences
Research
Council (BBSRC), United Kingdom Research
and Innovation,
March, 2018.
Orthopedic, Skeletal Muscle, and Oral Sciences Study
Section (ZRG1 MOSS D10) (SBIR/STTR grants) for NIH on June 13-14, 2019.
Musculoskeletal, Oral, and Skin Sciences AREA Study
Section (R15) ZRG1 MOSS D82 for NIH on June 14, 2019.
Skeletal Muscle and Exercise Physiology Study Section (2020/01 SMEP) for NIH on
October 7-8, 2019.
Scientific Presentations:
Dr.
Waddell and his students participated at the
Annual Experimental Biology Conference
in Orlando, FL April 4-7, 2019. His group of students
presented their ongoing research.
Undergraduate
Posters from Experimental Biology Conference
(undergraduate
students from UNF are bolded; * Presented by):
Aimee
Cruikshank*,
Sarah Lynch and David Waddell. Ubiquitin
Specific Peptidase 3 (USP3) is Expressed in Skeletal Muscle and is Upregulated
in Response to Neurogenic Atrophy.
Tala
Tello*
and David Waddell. Identification and Characterization of
TSSK6 Activating Co-Chaperone (TSACC) in Skeletal Muscle.
Parker
Irvin*,
Kelsey Patterson, and David Waddell. Identification and
Characterization of Calcium Binding and Coiled Coil Domain 1 (Calcoco1) in
Skeletal Muscle.
Alexandra
Arcaro*, Lillian Hewitt*
, and David Waddell. Identification and
Characterization of Homocysteine Responsive Endoplasmic Reticulum Resident
Ubiquitin-like Domain Member 2 (Herpud2) in Skeletal Muscle.
Ciara
Golliher*, Anjelican DaSilva*
, and David Waddell.
Identification and Characterization of TNF Receptor Associated Factor 3
Interacting Protein 3 in Skeletal Muscle..
Jack
Kavanagh*,
Lisa Cooper, and David Waddell. Characterization of the
Regulation of Family with Sequence Similarity 83 Member D (Fam83D) in Skeletal
Muscle.
Keri
Wortherly*
and David Waddell. Identification and Characterization of
Ovarian Tumor Protease Domain Containing 1 (OTUD1) in Skeletal Muscle.
Adrianna
White*
and David Waddell. F-box and WD-40 Domain Protein 5 (Fbwx5)
and F-box Protein 44 (Fbxo44) are Expressed in Skeletal Muscle.
Graduate
Student Posters from Experimental Biology
(Graduate students
from UNF are bolded; * Presented by):
Sydney
Labuzan*
and David Waddell. Identification and Characterization of
Protein Phosphatase Methylesterase (Ppme1) in Skeletal Muscle.
Sarah
Lynch*
and David Waddell. Identification and Characterization of
1700029J07RIK, a Novel Gene Expressed in Skeletal Muscle.
Lisa
Cooper*
and David Waddell. Dual Specificity Phosphatase and Pro
Isomerase Containing 1 (Dupd1) is Upregulated During Skeletal Muscle Atrophy
and is Differentially Expressed in MuRF1-null Mice.
Anastasia
Smith
*
and
David Waddell. Identification and Characterization of Allograft Inflammatory
Factor-1 Like (Aif1L) in Skeletal Muscle.
Publications:
In an
APSselect manuscript
entitled “Dual-Specificity Phosphatase 4 (Dusp4) is Upregulated During Skeletal
Muscle Atrophy and Modulates Extracellular Signal-Regulated Kinase (ERK)
Activity”, the Waddell lab group in the Biology Department at the
University of North Florida showed for the first time that Dusp4 is expressed
in skeletal muscle and is upregulated during neurogenic muscle atrophy.
Furthermore, the findings from this study show that Dusp4 binds to ERK1/2, but
not p38 or JNK, in muscle cells and inhibits MAP kinase signaling and muscle
cell differentiation. The results of this study strongly suggest that the MAP
kinase signaling pathway may play an important role in the muscle atrophy
cascade and that Dusp4 could be a potential druggable target for the prevention
or treatment of muscle wasting associated with chronic disease states, such as
cancer, cardiovascular disease, and Alzheimer’s, as well as, aging-associated
muscle loss.
Congratulations to Dr. Waddell and his group of
students for their accomplishments.