Dr. David Waddell
My research interests lie in better elucidating the cellular pathway involved in the process of skeletal muscle atrophy. My research in particular focuses on the isolation and functional analysis of dihydrousidine synthase 2 (Dus2), a gene that is expressed in skeletal muscle cells. This gene’s expression has been shown to be transcriptionally regulated by MuRF1, an E3 ubiquitin ligase. Dus2 expression has already been seen to be upregulated by MuRF1 under conditions of neurogenic atrophy, and is hypothesized to be a regulator of translational machinery and involved in cell viability in pulmonary cells. However, its role has never been functionally analyzed in skeletal muscle, so better understanding its function within the atrophy pathway will help to better understand the underlying molecular mechanisms of neurogenic skeletal muscle atrophy.
B.S. Biology, Rollins College