Areas of Expertise
Molecular and Cell Biology, Molecular Biology Techniques, Cellular Biology, Cell and Molecular Neuroscience, Immunology, Molecular Biology and Biochemistry
B.A. (Biochemistry) Wilkes University (1994)
Ph.D. (Biochemistry Program) The Ohio State University (1998)
Post-doctoral training – University of Florida, Whitney Laboratory
My research group focuses on molecular interactions involving Basigin gene products. These members of the immunoglobulin superfamily are cell adhesion molecules that have been implicated in neurological behaviors including vision, olfaction, and learning and memory, as well as reproduction, cancer, and Alzheimer’s disease. We use cell and molecular biology and biochemistry techniques to answer questions related to the in cis (in the same cell) and in trans (between different cells) binding partners of Basigin gene products in the hopes of understanding the biological mechanisms mediated via these interactions.
UNF Outstanding Undergraduate Teaching Award, April 2012
UNF Mentor of the Year Award, 1st runner-up, April 2011
UNF Outstanding Undergraduate Teaching Award, April 2009
Publications & Presentations
Ochrietor, J.D., Moroz, T. P., and Linser, P.J. 2010. The 2M6 antigen is a Müller cell-specific intracellular membrane-associated protein of the sarcolemmal membrane-associated protein family and is also TopAP. Molecular Vision 16, 961-969.
Howard, J., Finch, N. A., and Ochrietor, J.D. 2010. Characterization of monocarboxylate transporter 1 (MCT1) binding affinity for Basigin gene products and L1cam. Cellular and Molecular Neurobiology, 30, 671-674. DOI 10.1007/s10571-010-9503-2.
Finch, N. A., Linser, P. J., and Ochrietor, J. D. 2009. Hydrophobic interactions stabilize the Basigin-MCT1 complex. Protein Journal 28: 362-368. DOI 10.1007/ s10930-009-9202-3
Ochrietor, J. D., Clamp, M. F., Moroz, T. P., Grubb, J. H., Shah, G. N., Waheed, A., Sly, W. S., and Linser, P. J. 2005. Carbonic anhydrase-XIV identified as the membrane CA in mouse retina: Strong expression in Müller cells and the RPE. Exp. Eye Res 81: 492-500.
Ochrietor, J. D. and P. J. Linser. 2004. 5A11/Basigin gene products are necessary for proper maturation and function of the retina. Dev. Neurosci. 26: 380-387.
Clamp, M. C., J. D. Ochrietor, T. P. Moroz, and P. J. Linser. 2004. Developmental expression of 5A11/Basigin family members in the mouse retina. Exp. Eye Res. 78: 777-789.
Ochrietor, J. D., T. P. Moroz, L. van Ekeris, M. F. Clamp, S. C. Jefferson, A. C. V. deCarvalho, J. M. Fadool, G. Wistow, T. Muramatsu, and P. J. Linser. 2003. Retina-specific expression of 5A11/Basigin-2, a member of the immunoglobulin gene superfamily. Invest. Ophthal. Vis. Sci. 44: 4086-4096.
Philp, N. J., J. D. Ochrietor, C. Rudoy, T. Muramatsu, and P. J. Linser. 2003. Loss of MCT1, MCT3 and MCT4 expression in the retinal pigmented epithelium and neural retina of the 5A11/Basigin null mouse. Invest. Ophthal. Vis. Sci. 44: 1305-1311.
Ochrietor, J. D., T. P. Moroz, M. F. Clamp, A. M. Timmers, and P. J. Linser. 2002. Inactivation of the Basigin gene impairs normal retinal development and maturation. Vis. Res. 42: 447-453.
Ochrietor, J. D., T. Moroz, K. Kadamatsu, T. Muramatsu, and P. J. Linser. 2001. Retinal degeneration following failed photoreceptor maturation in 5A11/Basigin null mice. Exp. Eye Res. 72: 467-77.