Abdul H Fauq

Adjunct • Visiting Lab-lecturer

Chemistry • College of Arts & Sciences

Areas of Expertise

Organic synthesis of natural and medicinally important products and pharmacological tools

Education

Ph.D. Synthetic Organic Chemistry

University of Hawaii, Honolulu

1984

 

M.S. Organic Biochemistry

University of Punjab, Pakistan

1972

 

B.S. Organic Biochemistry

University of Punjab, Pakistan

1970

 

Biography

Grants and Contracts Awarded

As a Core director at Mayo Clinic Jacksonville, I have been a part of several NIH-funded grants

Publications & Presentations

PUBLICATIONS:

(A): IN CHEMITRY/MEDICINAL CHEMISTRY JOURNALS

J. Am. Chem. Soc.
(Impact Factor 9.02 by ISI (JCR)’s official IF ranking 2010)

1. Tius, M. A.; Fauq, A. H. Total Synthesis of (-)-Asperdiol. J. Am. Chem. Soc. 1986, 108, 6389.

2. Tius, M. A.; Astrab, D. P.; Fauq, A. H.; Ousset, J.-B.; Trehan, S. Cationic
Cyclopentannelation: An Efficient Methylenomycin Synthesis. J. Am. Chem. Soc. 1986, 108, 3438.

3. Tius, M. A.; Fauq, A. H. Total Synthesis of (+)-Desepoxyasperdiol. J. Am. Chem. Soc. 1989, 108, 1035.

4. Kozikowski, A. P.; Fauq, A. H.; Aksoy, S.; Seewald, M. J.; Powis, G. Synthesis of the First Optically Pure, Fluorinated Inositol 1,4,5-Tris-phosphate of myo-Inositol Stereochemistry and Its Effect on Ca2+Release in Swiss 3T3 cells. J. Am. Chem. Soc. 1990, 112, 7403.

5. Kozikowski, A. P.; Fauq, A. H.; Powis, G.; Melder, D. C. Efficient Synthetic Routes to Fluorinated Isosteres of Inositol and Their Effect on Cellular Growth. J. Am. Chem. Soc. 1990, 112, 4528.

6. Kozikowski, A. P.; Ognyanov, V. I.; Fauq, A. H.; Wilcox, R. A.; Nahorski, S. R. Synthesis of 1D-3-Deoxy-, 1D-2,3-Dideoxy-, and 1D-2,3,6-Trideoxy-myo-Inositol 1,4,5-Trisphosphate from Quebrachitol, Their Binding Affinities and Calcium Release Activity. J. Am. Chem. Soc. 1993, 115, 4429.

J. Org. Chem.
(Impact Factor 4.00 by ISI (JCR) official IF ratings 2010)

1. Tius, M. A.; Fauq, A. H.; Copper-Catalyzed Reactions of 2,3- Epoxyalcohols. J. Org. Chem. 1983, 48, 4131.

2. Kozikowski, A. P.; Powis, G.; Fauq, A. H.; Tückmantel, W.; Gallegos, A. Synthesis and Biological Activity of the D-3-Deoxy-3-fluoro and D-3-chloro-3-deoxy Analogues of Phosphatidylinositol. J. Org. Chem. 1994, 59, 963.

3. Kozikowski, A. P.; Fauq, A. H.; Wilcox, R. A.; Nahorski, S. R. Tools Cell Signalling: Synthesis of the 3-Phosphatase Resistant 1,3,4,5-InsP3 Mimic, 1D-1,4,5-Trisphosphate 3-phosphrothioate. J. Org. Chem. 1994, 59, 2279.

J. Med. Chem.
(Impact Factor 5.21 by ISI (JCR) official IF ratings 2005)

1. Kozikowski, A. P.; Ognyanov V. I.; Chen C.; Fauq, A. H.; Safrany, S. T.; Wilcox, R. A.; Nahorski, S. R. Deoxygenated Inositol Analogs and Their interaction with Metabolic Enzymes. (1R,2R,4R)-Cyclohexane 1,2,4-Tris(methylenesulphonate): A Potent Selective Inhibitor. J. Med. Chem. 1993, 36, 3035.

2. Kozikowski, A. P.; Fauq, A. H.; Wilcox, R. A.; Challiss, R. A. J.; Nahorski, S. R. The Novel Ins(1,4,5)P3 Analog, 3-Amino-3-deoxy-Ins(1,4,5)P3, is a pH Dependent Ins(1,4,5)P3 Receptor Partial Agonist in SH-SY5Y Neuroblastoma Cells. J. Med. Chem. 1994, 37, 868.

Bioconjug. Chem.
(Impact Factor 5.002 by ISI (JCR) official IF ratings 2010)

1. Fauq, A. H..; Kache, R.; Khan, M. A.; Vega, I. E. Synthesis of Acid-Cleavable Light Isotope-Coded Affinity Tags (ICAT-L) for Potential Use in Proteomic Expression
Profiling Analysis. Bioconjug Chem. 2006, 17, 248-54.

Tetrahedron lett.
(Impact Factor 2.618 by ISI (JCR) official IF ratings 2010)

1. Maharvi, G. M.; Edwards, A. O.; Fauq, A. H. Chemical synthesis of deuterium-labeled and unlabeled very long chain polyunsaturated fatty acids. Tetrahedron Lett. 2010, 51, 6426-6428.

2. Maharvi, G. M.; Fauq, A. H. A synthesis of the gamma-secretase inhibitor BMS-708163.
Tetrahedron Lett. 2010, 51, 6542-6544.

Bioorg. Med. Chem. Lett.
(Impact Factor 2.661 by ISI (JCR) official IF ratings 2010)

1. Fauq A, H.; Simpson, K.; Maharvi, G. M.; Golde, T.; Das, P. A multigram chemical synthesis of the gamma-secretase inhibitor LY411575 and its diastereoisomers. Bioorg. Med. Chem. Lett. 2007, 17, 6392-6395.

2. Fauq, A. H.; Maharvi, G. H.; Sinha, D. A convenient synthesis of (Z)-4-hydroxy-N-desmethyltamoxifen (endoxifen). Bioorg. Med. Chem. Lett. 2010, 20, 3036-3038.

3. Kozikowski, A. P.; Fauq, A. H.; Miller, J. H.; McKinney, M. Alzheimer's Therapy: An Approach to Novel Muscarinic Ligands Based upon the Naturally Occurring Alkaloid Himbacine. Bioorg. Med. Chem. Lett. 1992, 2, 797.

4. Malaska, M. J.; Fauq, A. H.; Kozikowski, A. P.; Aagaard, P. J.; Mckinney, M. Simplified Analogs of Himbacine Displaying Potent Binding Affinity to Muscarinic Receptors. Bioorg. Med. Chem. Lett. 1993, 3, 1247.

5. Kozikowski, A. P.; Fauq, A. H.; Wilcox, R. A.; Nahorski, S. R. Chemical Synthesis and Biological Evaluation of 1D-1,2,4,5 Ins P4 and Its 3-Fluorinated Counterpart 1-D-3-F-1,2,4,5-Ins P4—Potent 1D-1,4,5-Ins P3-like Calcium Mobilising Analogs. Bioorg. Med. Chem. Lett. 1995, 5, 1295-1300.


Synlett
(Impact Factor 2.44 by ISI (JCR) official IF ratings 2010)

1. Fauq, a. h.; Maharvi, G. H.; Sinha, D. A convenient synthesis of (Z)-4-hydroxy-N- desmethyltamoxifen (endoxifen). Bioorganic & Medicinal Chemistry Letters, 2010, 20, 3036-3038.

2. Kozikowski, A. P.; Fauq, A. H.; Powis, G.; Melder, D. C. D-3-Modified myo-Inositol Analogues: Synthesis and Growth Inhibitory Properties. Med. Chem. Res. 1991, 1, 277.

3. Kozikowski, A. P.; Fauq, A. H.; Tückmantel, W.; Casalotti, S. O.; Krueger, K. E. Synthesis of N-[1-(2-Thienyl)cyclohexyl]piperidine (TCP) Based Irreversible Alkylators of the Phenylcyclidine (PCP) Recognition Site. Synlett 1991, 9, 654.

4. Kozikowski, A. P .; Fauq, A. H. Synthesis of Novel Four-Membered Ring Amino Acids as Modulators of the NMDA Receptor Complex. Synlett 1991, 11, 783.

Tetrahdron: Asymmetry
(Impact Factor 2.48 by ISI (JCR) official IF ratings 2010)

1. Fauq, A. H.; Cherif, C.-Z.; Richelson, E. Synthesis of (S)- and (R)-enantiomers of p-(4- hydroxybenzoyl)phenylalanine, useful photoaffinity labeling probes for peptide-protein binding sites. Tetrahedron: Asymmetry, 1998, 9, 2333-2338.

2. Fauq, A. H.; Hong, F.; Cusack, B.; Tyler, B. M.; Pang, Y.-P.; Richelson, E. Synthesis of (2S)-2-Amino-3-(1H-4-indolyl)propanoic Acid, A Novel Tryptophan Analog for Structural Modification of Bioactive Peptides. Tetrahedron: Asymmetry, 1998, 9, 4127-4134.

Synthetic Communications
(Impact Factor 0.937 by ISI (JCR) official IF ratings 2010)

3. Fauq, A.H.; Khan, M. A.; Eckman, C. A concise, high yield synthesis of ECE-inhibitor CGS 35066. Synth. Commun. 2004, 34, 775-782.


(B): IN SCIENCE/PHARMACOLOGY JOUNALS

Nature
(Impact Factor 28.878 [medicine] and 36.1 [Immunolgy] by ISI (JCR)’s official IF ranking 2010)

1. Kukar, T.; Murphy, M. P.; Eriksen, J. L.; Sagi, S. A.; Weggen, S.; Smith, T. E.; Ladd, T.; Khan, M. A.; Kache, R.; Beard, J.; Dodson, M.; Merit, S.; Ozols, V. V.; Anastasiadis, P. Z.; Das, P.; Fauq A.; Koo, E. H.; Golde, T. E. Diverse compounds mimic Alzheimer disease-causing mutations by augmenting A beta 42 production. Nature Medicine 2005, 11, 545-550.

2. Minter, L.M.; Turley, D. M.; Das, P.; Shin, H. M.; Joshi, I.; Lawlor, R. G.; Cho, O. H.; Palaga, T.; Gottipati, S.; Telfer, J. C.; Kostura, L.; Fauq, A. H.; Simpson, K.; Such, K. A.; Miele, L.; Golde, T. E.; Miller, S. D.; Osborne, B. A. Inhibitors of gamma-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21. Nature Immunology 2005, 6, 680-688.

3. Kukar, T. L.; Ladd, T. B.; Bann, M. A.; Fraering, P. C.; Narlawar, R.; Maharvi, G. M.; Healy, B. Chapman, R.; Welzel, A. T.; Price, R. W.; Moore, B; Rangachari, V.; Cusack, B.; Eriksen, E; Jansen-West, K.; Verbeeck, C.; Debra D.; Eckman, C.; Ye, W.; Sagi, S.; Cottrell, B. A.; Torpey, J. Rosenberry, T. L.; Fauq, A. H.; Wolfe, M. S. M. W.; Schmidt, B.; Walsh, D. A.; Koo, E. H.; Golde, T. E. Substrate-targeting gamma-secretase modulators, Nature 2008, 453, 925-930.

Proc. Natl. Acad. Sci.
(Impact Factor 9.77 by ISI (JCR)’s official IF ranking 2010)

1. Tyler, B.; Jansen, K.; Mccormick, D. J.; Douglas, C. L.;, Boules, M.;
Stewart, J. A.; Zhao, L.; Lacy, B.; Cusack, B.; Fauq, A.; Richelson, E. . Peptide Nucleic Acids Targeted to the Neurotensin Receptor and Administered I.P. Cross the Blood-brain Barrier and Specifically Reduce Gene Expression. Proc. Natl. Acad. Sci. USA. 1999, 96, 7053-7058.

2. Spilman, P.; Lessard, P.; Sattavat, M.; Bush, C.; Tousseyn, T.; Huang, E.; Giles, K.; Golde, T.; Das, P.; Fauq, A.; Prusiner, S.; (1992), DeArmond, S. "A γ-secretase inhibitor and quinacrine reduce prions and prevent dendritic degeneration in murine brains". Proc. Natl. Acad. Sci., U.S.A. 2008, 105, 10595-10600.

Blood
(Impact factor 10.56 by ISI (JCR)’s official IF ranking 2010)

1. Joshi, I.; Minter, L. M.; Telfer, J.; Demarest, R. M.; Capobianco, A. J.; Aster, J, C.; Sicinski, P.; Fauq, A.; Golde, T. E.; Osborne, B. A. Notch signaling mediates G1/S cell cycle progression in T cells via cyclin D3 and its dependent kinases. Blood 2009, 113. 1189-98.

2. Joshi, I.; Minter, L. M.; Telfer, J.; Demarest, R. M.; Capobianco, A. J.; Aster, J. C.; Sicinski, P.; Fauq, A.; Golde, T. E.; Osborne, B. A. Notch1 and TGFβ1 cooperatively regulate Foxp3 expression and the maintenance of peripheral regulatory T cells. Blood 2008, 112, 1813-1821.

J. Clin. Oncol.
(Impact Factor 18.97 by ISI (JCR)’s official IF ranking 2010)

1. Pockaj, B. A.; Gallagher, J. G.; Loprinzi, C. L.; Stella, P. J.; Barton, D. L.; Sloan, J. A.; Lavasseur, B. I.; Rao, R. M.; Fitch, T, M.; Rowland, K. M.; Novotny, P. J.; Flynn, P. J; Richelson, E.; Fauq, A. H. A Phase III Double-Blind, Randomized, Placebo-Controlled Crossover Trial of Black Cohosh in the Management of Hot Flashes: NCCTG Trial N01CC1. J. Clinical Oncol. 2006, 24, 2836-2840.

EMBO Journal
(Impact Factor 10.12 by ISI (JCR)’s official IF ranking 2010)

1. Shin, H. M.; Minter.; L. M.; Cho.; O. H.; Gottipati;, S.; Fauq, A. H.; Golde, T. E.; Sonenshein, G. E.; Osborne, B. A. Notch1 augments NF-kappa B activity by facilitating its nuclear retention. Embo Journal 25, 2006, 129-138.

J. Biol. Chem.
(Impact Factor 5.33 by ISI (JCR)’s official IF ranking 2010)

1. Wilcox, R. A.; Challis, R. A. J.; Traynor, J. R.; Fauq, A. H.; Ognayanov, V. I.; Kozikowski, A. P.; Nahorski, S. R. Molecular Recognition at the myo-inositol 1,4,5-Trisphosphate Receptor---3-Position Substituted myo-Inositol 1,4,5-Trisphosphate Analogues Reveal the Binding Ca++ Release Requirements for High Affinity Interaction with the myo-Inositol 1,4,5-trisphosphate Receptor. J. Biol. Chem. 1994, 269, 26815.

2. Cusack, B.; McCormick, D. J.; Pang, Y-.P.; Souder, T.; Garcia, R.; Fauq, A.; Richelson, E. Pharmacological Profiles of Unique Neurotenson 8-13 Analogs Exhibiting Species Selectivity, Stereoselectivity, and Superagonism. J. Biol. Chem., 1995, 270, 18359-18366.

3. Murphy, M. P.; Uljon, S. N.; Fraser, P. E.; Fauq, A.; Lookingbill, H. A.; Findlay, K. A.; Smith, T. E.; Lewis, P. A.; McLendon, D. C.; Wang, R.; Golde, T. E. Presenilin 1 Regulates Pharmacologically Distinct {gamma}-SecretaseActivities: Implications for the Role of PS in gamma}-Secretase Cleavage. J. Biol. Chem. 2000, 275: 26277-26284.

4. Johnson, J. L.; Cusack, B.; Hughes, T. F.; McCullough, E. H.; Fauq, A.; Romanovskis, P.; Spatola, A. F.; Rosenberry, T. L. Inhibitors tethered near the acetylcholinesterase active site serve as molecular rulers of the peripheral and acylation sites. J. Biol Chem. 2003, 278, 38948-55.

5. Weggen, S.; Eriksen, J. L.; Sagi, S. A.; Pietrzik, C. U.; Ozols V.; Fauq, A.; Golde, T. E.; Koo, E. H. Evidence that nonsteroidal anti-inflammatory drugs decrease amyloid beta 42 production by direct modulation of gamma-secretase activity. J. Biol. Chem. 2003, 278:31831-31837.

6. Nyborg, A. C; Jansen, K; Ladd, T.B; Fauq, A; Golde, T. E: A Signal Peptide Peptidase reporter (SPP) activity assay based on the cleavage of type II membrane protein substrates provides further evidence for an inverted orientation of the SPP active site relative to presenilin. J. Biol. Chem. 2004, 279, 43148-43156.

7. Eckman, E. A.; Adams, S. A.; Troendle, F. J.; Stodola, B. A.; Khan, M.A.; 1, Fauq, A. H.; Xiao, H. D.; Bernstein, K. E.; Eckman, C. B. Regulation of steady-state β-amyloid levels in the brain by neprilysin and endothelin-converting enzyme, but not angiotensin-converting enzyme, J. Biol. Chem. 2006, 281, 30471-30478.

8. Li, T.; Wen, H.; Brayton, C.; Das, P.; Smithson, L. A. Fauq A.; Fan, X.; Crain, B. J.; Price, D. L.; Golde, T. E.; Eberhart, C. G.; Wong, P. C. Epidermal growth factor receptor and notch pathways participate in the tumor suppressor function of gamma-secretase. J. Biol. Chem. 2007, 282, 32264-32273.

9. Pigment epithelium-derived factor maintains retinal pigment epithelium function by inhibiting vascular endothelial growth factor-R2 signaling through gamma-secretase.
Ablonczy, Z.; Prakasam, A.; Fant, J.; Fauq, A.; Crosson, C.; Sambamurti, K. J. Biol. Chem. 2009, 284, 30177-30186.

10. Chadli, A. Felts, S. J.; Wang, Q.; Sullivan, W. P.; Botuyan, M. V.; Fauq, A.; Ramirez-Alvarado, M.; Mer, G. Celastrol inhibits Hsp90 chaperoning of steroid receptors by inducing fibrillization of the Co-chaperone p23. J. Biol.Chem. 2010, 285, 4224-4231.

Biochemistry
(Impact Factor 3.23 by ISI (JCR)’s official IF ranking 2010)

1. Dwyer, T. M.; Mortl, S.; Kemter, K.; Bacher, A.; Fauq, A.; Frerman, F. E. The Intraflavin Hydrogen Bond in Human Electron Transfer Flavoprotein Modulates Redox Potentials and may Participate in Electron Transfer. Biochemistry 1999, 38, 9735-9745.

2. Johnson, J. L.; Cusack, B.; Davies, M. P.; Fauq, A.; Rosenberry, T, L. Unmasking tandem site interaction in human acetylcholinesterase. Substrate activation with a cationic acetanilide substrate. Biochemistry 2003, 42:5438-5452.

3. Poduslo, J. F.; Curran, G. L.; Peterson, J. A.; McCormick, D.J.; Fauq, A.H.; Khan, M. A; Wengenack, T. M. Design and Chemical Synthesis of a Magnetic Resonance Contrast Agent with Enhanced in Vitro Binding, High Blood-Brain Barrier Permeability, and in Vivo Targeting to Alzheimer's Disease Amyloid Plaques. Biochemistry 2004, 43, 6064-6075.

4. Sala Frigerio C.; Kukar, T. L.; Fauq, A.; Engel, P. C.; Golde, T. E.; Walsh, D. M. An NSAID-like compound, FT-9, preferentially inhibits gamma-secretase cleavage of the amyloid precursor protein compared to its effect on amyloid precursor-like protein 1.
Biochemistry 2009, 48, 10894-10904.

Clin. Chem.
(Impact Factor 6.89 by ISI (JCR) official IF ratings 2010)

1. Seegmiller, J. C.; Burns, B. E.; Fauq, A. H.;. Mukhtar, N.; Lieske, J. C.; Larson, T. S.
Iothalamate quantification by tandem mass spectrometry to measure glomerular filtration rate. Clin. Chem. 2010, 56, 568-574.

J. Immunol.
((Impact Factor 5.74 by ISI (JCR) official IF ratings 2010)

1. Cho, O. H.; Shin, H. M.; Miele, L.; Golde, T. E.; Fauq, A.; Minter, L. M.; Osborne, B. A.; Notch regulates cytolytic effector function in CD8+ T cells. J. Immunol. 2009, 182(6):3380-9.

FASEB Journal
((Impact Factor 6.5 by ISI (JCR) official IF ratings 2010)

1. McLendon, C.; Xin T. P.; Ziani-Cherif, C.; Murphy M. P.; Findlay, K. A.; Lewis, P. A.; Pinnix, I.; Sambamurti, K.; Wang, R.; Fauq A.; Golde T. E. Cell-free Assays for Gamma-secretase Activity. FASEB J. 2000, 14, 2383-2386.

J. Neurosci.
((Impact Factor 7.27 by ISI (JCR) official IF ratings 2010)

1. Fitz, N. F; Cronican, A.; Pham, T. Fogg, F.; Fauq, A. H.; Chapman, R.; Lefterov, I.; Koldamova, R. Liver X Receptor Agonist Treatment Ameliorates Amyloid
Pathology and Memory Deficits Caused by High-Fat Diet in APP23 Mice. J. Neurosci. 2010, 30, 6862– 6872.

PLoS One
((Impact Factor 4.41 by ISI (JCR) official IF ratings 2010)

1. Leissring, M. A.; Malito, E.; Hedouin, S.; Reinstatler, L.; Sahara, T; Abdul-Hay, S. O.; Choudhry S;, Maharvi, G. M; Fauq, A. H,; Huzarska, M, May, P. S.; Choi, S.; Logan, T. P.; Turk, B. E.; Cantley, L. C.; Manolopoulou, M.; Tang, W. J; Stein, R. L.; Cuny, G. D.; Selkoe, D. J. Designed inhibitors of insulin-degrading enzyme regulate the catabolism and activity of insulin. PLoS One 2010, 5(5):e10504.

2. Parvanova, I.; Epiphanio, S.; Fauq, A.; Golde, T. E.; Prudencio, M.; Mota, M. M. A small molecule inhibitor of signal peptide peptidase inhibits Plasmodium development in the liver and decreases malaria severity. PLoS ONE 2009, 4(4):e5078.

Other publications

1. Zaidi, J. H.; Fauq, A. H.; Khan, N.; Abbasi, M. A.; Iqbal, M. Hofmann Reaction Studies of Biuret. Islamabad J. Sci., 1975, 14, 32.

2. Casalotti, S.; Kozikowski, A. P.; Fauq, A.; Tückmantel, W.; Krueger, K. E. Design of an Irreversible Affinity Ligand for the Phencyclidine Recognition Site on N-Methyl-D-Asparate Type Glutamate Receptors. J. Pharmacol. Exp. Ther. 1992, 260, 21.

3. Reynolds, I. J.; Rothermund, K.; Rajdev, S.; Fauq, A. H.; Kozikowski, A. P. [125I] Thienylphencyclidine, A Novel Ligand for the NMDA Receptor. Eur. J. Pharmacol. 1992, 226, 53.

4. Casalotti, S. O.; Kozikowski, A. P.; Fauq, A.; Tueckmantel, W.; Krueger, K. E. Monoclonal Antibodies Against a Phencyclidine Derative are Used to Investigate Protein-Ligand Interactions. Eur. J. Pharmacol., 1993, 247, 209-213.

5. Brunn, G.; Fauq, A. H.; Chow, S.; Kozikowski, A. P.; Powis, G. Cellular Pharmacology of D-3-Azido-3-Deoxy-myo-Inositol, An Inhibitor of Phosphatidylinositol Signalling Possessing Antiproliferative Activity. Cancer Chemother. Pharmacol. 1994, 35, 71.

6. Fauq, A. H.; Kozikowski, A. P.; Gallegos, A.; Powis, G. Total Synthesis of 3-Chloro-3-Deoxy-1-O-(1,2-Di-O-Palmitoyl-sn-Glycero-3-Phospho)-D-myo-Inositol. A Potential Mechanistic Probe for Phosphoinositide Signal Tranasduction Pathways. Med. Chem. Res. 1993, 3, 17.

7. Powis, G.; Aksoy, I. A.; Melder, D. C.; Aksoy, S.; Eichinger, H.; Fauq, A. H.; Kozikowski, A. P. D-3-Deoxy-3-Substituted myo-Inositol Analogues as Inhibitors of Cell Growth. Cancer Chemother. Pharmacol. 1991, 29, 95.

8. Kozikowski, A. P.; Fauq, A. H.; Malaska, M. J.; Tückmantel, W.; Ognyanov, V. Novel Signal Molecules as Potential Anticancer Agents. Curr. Med. Chem. 1995.

9. Malaska, M. J.; Fauq, A. H.; Kozikowski, A. P.; Aagaard, P. J.; McKinney, M. Chemical Modification of Ring C of Himbacine: Discovery of a Pharmcophoric Element for M2 Selectivity. Bioorg. Med. Chem. Lett. 1995, 5, 61.

10. Mays, D. C.; Nelson, A. N.; Fauq, A. H.; Shriver, Z. H.; Veverka, K. A.;
Nayor, S.; Lipsky, J. J. S-Methyl N,N-Diethylthiocarbamate Sulphone, A Potential Metabolite of Disulfuram and Potent Inhibitor of Low Km Mitochondrial Aldehyde Dehydrogenase. Biochem. Pharmacol. 1995, 49, 693.

11. Mays, D. C.; Nelson, A. N.; Lam-Holt, J.; Fauq, A. H.; Lipski, J. J. S-Methyl-N,N-Diethylthiocarbamate Sulfoxide and S-Methyl-N,N-Diethylthiocarbamate Sulfone, Two Candidates for the Active Metabolite of Disulfuram. Alcoholism: Clin. Exp.. Res., 1996, 20, 595-600.

12. Willard, J.; Vicanic, C.; Battaile, K. P.; VanveldhOven, P. P.; Fauq, A. H.; Rozen, R.; Vockley, J. Cloning of a CDNA for Short/Branched Chain Acyl Co-A Dehydrogenbase from Rat and Characterization of its Tissue Expression and Substrate Specity. Arch. Biochem. Phys., 1996, 331, 127-133.

13. Wilcox, R. A.; Fauq, A.; Kozikowski, A. P.; Nahorski S. R. Defining the Minimal Structural Requirements for Partial Agonism at the Type 1 myo-Inositol1,4,5-Trisphosphate Receptor. FEBS Letters. 1997, 402, 241-245.

14. Hong, F.; Cusack B.; Fauq, A.; Rchelson, E. Peptidic and non-Peptidic Neurotensin Analogs. Curr. Med. Chem. 1997, 4, 421-434.

15. Mays, D. C.; Ortiz-Bermudez, P.; Lam, J. P.; Tong, I. H.; Fauq, A. H.; Lipsky, J. J. Inhibition of Recombinant Mitochondrial Aldehyde Dehydrogenase by Two Intermediate Metabolites of Disulfuram. Biochem. Pharmacol. 1998, 49, 1090-1103.

16. Epn, L. J.;; Sandborn, W. J.; Mays, D. C.; Tremaint, W. J.; Fauq, A. H.; Lipsky, J. J. Systemic and Intestinal Pharmacokinetics of Methotrexate in Patients with Inflammatory Bowel Disease. Clin. Pharmacol. Ther. 1999, 65, 29-39.

17. Cusack, B.;Boules, B.; Tyler, B.M.; Fauq, A.; McCormick, D. J.; Richelson, E. Effects of a Novel Neurotensin Peptide Analog given Extracranially on CNS Behaviors Mediated by Apomorphine and Haloperidol, Brain Res., 2000, 856, 48-54.

18. Boules, M.; Cusack, B.; Zhao, L.; Fauq, A.; McCormick, D. J.; Richelson, E. A Novel Neurotensin Peptide Analog Given Extracranially Decreases Food Intake and Weight in Rodents. Brain Res., 2000, 865, 35-44.

19. Tyler-McMahon, B. M.; Stewart, J. A.; Jansen, K.; Ziani-Cherif, C.; Fauq, A.; Richelson, E. Peptide nucleic acids targeted to angiotensinogen lower mRNA levels, blood pressure and angiotensin I levels in rats. J. Clin. Pharmacol. 2000, 40, 1048,

20. Vockley J.; Mohsen A,W, A.; Binzak B. Willard J.; Fauq A.; Mammalian Branched-chain acyl-CoA Dehydrogenases: Molecular Cloning and Characterization of Recombinant Enzymes. Branched Chain Amino Acids, 2000, Pt. B, 324 PG. 241-258.

21. Murphy, M. P.; Wang R.; Fraser P. E.; Fauq A.; Golde, T. E. An Empirical Model of Gamma-secretase Activity. Annals of the New York Academy of Sciences. 2000, 920, 233-40.

22. McMahon, B. M.; Stewart, J. A.; Jackson, J.; Fauq, A.; McCormick, D. J.; Richelson, E.; Intraperitoneal Injection of Antisense peptide Nucleic Acids Targeted to the mu Receptor Decreases Response to Morphine and Receptor Protein Levels in Rat Brain, , Brain Res., 2001, 904, 345-349.

23. Ford, R. E.; Magera, M. J.; Kloke, K. M.; Chezick, P. A.; Fauq, A.; McConnell, J. P. Quantitative Measurement of Porphobilinogen in Urine by Stable-Isotope Dilution Liquid Chromatography-Tandem Mass Spectrometry. Clin. Chem. 2001, 47:1627-1632.

24. Boules, M.; Warrington, L.; Fauq, A.; McCormick, D.; Richelson, E. A novel neurotensin analog blocks cocaine- and D-amphetamine-induced hyperactivity. Eur J Pharmacol. 2001, 426, 73-6.

25. Tyler-McMahon, B. M.; Stewart, J. A.; Jackson, J.; Bitner, M. D. Fauq, A.; McCormick, D. J.; Richelson, E. Altering Behavioral Responses and Dopamine Transporter protein. Biochem. Pharmacol. 2001, 62, 929-932.

26. Boules, M.; Warrington, L.; Fauq, A.; McCormick, D.; Richelson, E. Antiparkinson-like Effects of a Novel Neurotensin Analog in Unilaterally 6-Hydroxydopamine Lesioned Rats. Eur. J. Pharmacol. 2001, 428:227-33.

27. Boules, M.; McMahon, B.; Warrington, L.; Stewart, J.; Jackson, J.; Fauq, A.; McCormick, D.; Richelson, E. Neurotensin analog selective for hypothermia over antinociception and exhibiting atypical neuroleptic-like properties. Brain Res, 2001, 919.1-11.

28. Murphy, M. P.; Wang, R.; Fraser, P. E.; Fauq, A.; Golde, T. E. An empirical model of gamma-secretase activity. Molecular Basis of Dementia 2000, 920, 233-240.

29. McMahon, B. M.; Stewart, J. A.; Bitner, M. D.; Fauq, A.; McCormick, D. J.; Richelson, E. Peptide nucleic acids specifically cause antigene effects in vivo by Systemic injection Life Sci, 2002, 71, 325-37.

30. McMahon, B. M,; Mays, D.; Lipsky, J.; Stewart, J. A.; Fauq, A.; Richelson, E.
Pharmacokinetics and tissue distribution of a peptide nucleic acid after
intravenous administration. Antisense Nucleic Acid Drug Dev. 2002, 12, 65-70.

31. Piper, S. C.; Amtul, Z; Galinanes-Garcia, L.; Howard, V. G.; Ziani-Cherif, C.; McLendon, C.; Rochette, Marjorie, J.; Fauq, A.; Golde, T. E. Peptide-based, irreversible inhibitors of gamma-secretase activity. Paul Murphy, M. Biochem. Biophys. Res. Commun. 2003, 305, 529-533.

32. McMahon B. M.; Stewart, J.; Fauq, A.; Younkin, S.; Younkin, L.; Richelson, E. Using peptide nucleic acids as gene-expression modifiers to reduce beta-amyloid levels. J. Mol. Neurosci 2002, 19, 71-6.

33. Eriksen J.; Monnier, T.; Das, P.; Fauq, A.; Khan, M.; McLendon, C.; Howard, V.;
Galinanes-Garcia, L.; Rochette, M.; Murphy, M. P.; Merit, S.; Golde, T. E.; Sagi, S.; Weggen, S.; Koo, E. Selective pharmacological manipulation of A beta 42 production. Neurobiology of Aging 2002, 23, 373.

34. Eriksen, J, L .; Das, P.; Wegen, S.; Eckman. C.; Murphy, M. P.; Nicolle, M.; Sagi, S. A.; Fauq, A.; Koo, E. H.; Golde, T. E.; In vivo effects and structure activity relationships of selective Abeta42 lowering agents. Society for Neuroscience Abstracts. 2001, 27, 2284.

35. Murphy, M. P.; Wang, R.; Frase, P. E.; Fauq, A.; Golde, T. E. An empirical model of gamma-secretase activity. [Book. Meeting] Growdon, J. H.; Wurtman, R. J.; Corkin, S.; Nitsch, R. M.: Authors. Annals of the New York Academy of Sciences. The molecular basis of dementia. 2000, 233-240.

36. McMahon, B. M.; Mays, De; Lipsky, J; Stewart, J. A.; Fauq, A; Richelson, E. Pharmacokinetics and tissue distribution of a peptide nucleic acid after intravenous administration. Antisense & Nucleic Acid Drug Development 2002, 12, 65-70.

37. Boules, Mona; McMahon, Beth; Warrington, Lewis; Stewart, Jennifer;
Jackson, Joshua; Fauq, Abdul; McCormick, Daniel; Richelson, E. Neurotensin analog selective for hypothermia over antinociception and exhibiting atypical neuroleptic-like properties. Brain Res., 2001, 919, 1-11.

38. Mcmahon, B.; Stewart, J.; Fauq, A.; Younkin, S.; Younkin, L.; Richelson, E. Peptide nucleic acid targeted to the Amyloid precursor protein. J. Mol. Neurosci., 2003, 20, 261-265.

39. Vockley, J.; Mohsen, al-W A.; Binzak, B.; Willard, J.; Fauq, A.; Mammalian branched-chain acyl-CoA dehydrogenases: molecular cloning and characterization of recombinant enzymes. Department of Medical Genetics, Mayo Clinic, Rochester, Minnesota 55905, USA. Methods enzymol. 2000, 324, 241-58.

40. Mead, J. R.; Fauq, A. H.; Khan, M. A.; Mcnair, N. Efficiency of Glycoconjugated Dinitroanilines against Cryptosporidium parvum. J. Eukaryot. Microbiol. 2003, 550.

41. Boules, M.; Williams, K.; Gollatz, E.; Fauq, A. H.; Richelson, E. Down-regulation of Amyloid Precurson Protein by Peptide Nucleic acid in vivo. J. Mol. Neurosci., 2004, 24, 123-128.

42. Venkatasubban, K. S.; Johnson, J. L.; Thomas, J. L.; Fauq, A.; Cusack, B.; Rosenberry, T. L. Steric effects in the decarbamoylation of carbamoylated acetylcholinesterases. Chemico-Biological Interactions, 2005, 157-158, 433-434.

43. Palaga Tanapat; Buranaruk Chayanit; Rengpipat Sirirat; Fauq Abdul H; Golde Todd E; Kaufmann Stefan H E; Osborne Barbara A Notch signaling is activated by TLR stimulation and regulates macrophage functions. Eur. J. Immunol., 2008, 38, 174-83.

44. Fischer, S. J.; Benson, L. M.; Fauq, A.; Naylor, S.; Windebank, A. J.; Cisplatin and dimethyl sulfoxide react to form an adducted compound with reduced cytotoxicity and neurotoxicity. Neurotoxicology 2008, 29, 444-452.

45. Garcia-Alloza, M.; Subramanian, M.;Thyssen, D.; Borrelli, L.A,; Fauq, A.;Das, P.; Golde, T. E.; Hyman, B. T.; Bacskai, B. J.; Existing plaques and neuritic abnormalities in APP:PS1 mice are not affected by administration of the gamma-secretase inhibitor LY-411575. Mol. Neurodegener. 2009, 4,19.
46. Rangachari, V.; Davey, Z. S.; Healy, B.; Moore, B. D.; Sonoda, L. K.; Cusack, B.; Maharvi, G. M.; Fauq, A. H.; Rosenberry, T. L. Rationally Designed Dehydroalanine (Delta Ala)-Containing Peptides Inhibit Amyloid-beta (A beta) Peptide Aggregation. Biopolymers 2009, 91, 456-465.
47. Prakasam, A.; Muthuswamy, A.; Ablonczy, Z.; Greig, N. H.; Fauq, A.; Rao, K. J.; Pappolla, M. A.; Sambamurti, K. Differential accumulation of secreted A-betaPP metabolites in ocular fluids. J. Alzheimers Dis. 2010, 20, 1243-1243.

48. Boules, M.; Liang, Y.; Briody, S.; Miura T.; Fauq, A.; Oliveros, A.; Wilson, M.; Khaniyev, S.; Williams, K. Li Z.; Qi Y.; Katovich, M.; Richelson, E. NT79: A novel neurotensin analog with selective behavioral effects. Brain Research 2010, 1308, 35-46.

49. Briody, S.; Boules, M.; Oliveros, A.; Fauq, A.; Richelson, E. Chronic NT69L potently prevents drug-induced disruption of prepulse inhibition without causing tolerance.
Behav Brain Res. 2010, 207, 118-24.

50. Bourassa, P.; Dubeau, S.; Maharvi, G. M.; Fauq, A. H.; Thomas, T. J.; Tajmir-Riahi, H. A. Binding of antitumor tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen to human serum albumin. Biochimie 2011, 93, 1089-101.

51. Smith, K. E.; Boules, M.; Williams, K.; Fauq, A. H.; Richelson, E. The role of NTS2 in the development of tolerance to NT69L in mouse models for hypothermia and thermal analgesia. Behav. Brain Res. 2011, 224:344-349.
52. Bourassa, P.; Dubeau, S.; Maharvi, G. M.; Fauq, A. H.; Thomas, T. J. ; Tajmir-Riahi, H. A. Locating the binding sites of anticancer tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen on bovine serum albumin. Eu. J. Med. Chem. 2011, 1-10.

53. Smith, K. E.; Boules, M.; Williams, K.; Fauq, A. H.; Richelson, E. The role of NTS2 in the development of tolerance to NT69L in mouse models for hypothermia and thermal analgesia. Behavioural Brain Research, 2011, 224, 344– 349.

54. Bourassa, P.; Dubeau, S.; Maharvi, G. M.; Fauq, A. H.; Thomas, T. J.; Tajmir-Riahi, H. A.
Locating the binding sites of anticancer tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen on bovine serum albumin. European Journal of Medicinal Chemistry. 2011, 46:4344-53.

(C): IN PROCESS/SUBMITTED

1. Maharvi, G. A.; Bharucha, A; Fauq, A. H. Synthesis of a DOTA(Gd3+)-conjugate of proton-pump inhibitor Pantoprazole for gastric wall imaging studies. Submitted to Bioconjugate Chemistry (2012).

2. Rosenberry, T.; Tay, W.; Beri, V.; Maharvi, G.; Fauq, A.H. Effect of acetylcholine esterase on the hydrolysis of (homo)acetylcholine and (nor)acetylcholine. Submitted to Biochemistry (2012).

3. Roderick, J.; Roberts, E.; Perez, G. G.; Dongre, A.; Arieta, C.; Chester, A.; Fauq, A. H.; Golde, T.; Osborne, B. Therapeutic targeting of Notch receptor-ligand signaling ameliorates immune-mediated bone marrow failure. Re-submitted to the J. Exp. Med. (2012).

4. Johnson, G. B.; Nathan, M. A.; Parisi, J. E.; Lingle, W. L.; Negron, V.; Hunt, C. H.; Peller, P. J.; Broski, S. M.; Fauq, A. H.; Jack, C. R.; Petersen, R. C.; Klunk, W. E.; Mathis, C. A.; Lowe, V. J.; Pittsburgh Compound B Positron Emission Tomography for Diagnosis of Meningiomas. New Eng. Med. Submitted (2012).

5. Roderick. J.; Perez, G. G.; Dongre, A.; Roberts, E.; Arieta, C.; Andrzejewski, C.; Fauq, A. H.; , Golde, T. E.; Miele, L.; Osborne, B. A.; Minter, M.; Inhibitors of gamma-secretase attenuate immune-mediated bone marrow failure by differentially regulating Notch receptor-ligand signaling. Submitted to Sci. Transl. Med. (2012).
6. Fitz, N. F.; Cronican, A.; Saleem, M.; Fauq, A. H.; Chapman, R.; Lefterov, I.; Koldamova, R.
Abca1 deficiency differentially affects AD-like phenotype in human ApoE4 but not in ApoE3 targeted replacement mice. Submitted to J. Neurosci.(2012).

REVIEWS:

Fauq, A. H. Diethylaminosulfur trifluoride. Encyclopedia of Organic Reagents 1995: John Wiley & Sons

 


REFERENCES:

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