Areas of Expertise
Research: Cell biology, molecular genetics, virology, yeast biology.
Teaching: Molecular & Cell Biology, Biology of Cancer, General Biology 1.
B.S. Muhlenberg College (1981)
Ph.D. Univ. of Alabama at Birmingham (1986)
Post-Doc UAB (1986-1987)
Post-Doc Univ. of California at Berkeley (1987-1991)
My laboratory is investigating mechanisms for regulation of DNA replication in eukaryotic cells. We are using the papillomaviruses as a model system for these studies, focusing on the role of phosphorylation of replication initiator proteins. The viral E1 replication protein is regulated both positively and negatively by phosphorylation. Mutation of E1 phosphate sites alters the virus replication phenotype. We are using genetic and biochemical methods to further elucidate regulatory pathways in the initiation of DNA synthesis.
A new research interest is physiology and biochemistry of new yeast isolates. We are collecting and characterizing yeast for a variety of physiological properties. Isolates are identified through RFLP mapping and DNA sequencing, and growth under variable conditions is investigated. We are also interested in characterizing yeast enzymes involved in the metabolism of cinammic acids, components of the plant cell wall on which the yeast reside. This project has both a basic and applied focus.
2001 - UNF Outstanding Undergraduate Teaching Award
American Society for Virology
Publications & Presentations
Luman E and Lentz M. 2011. The Accuracy of Pitching Yeast by Mass in a Small Microbrewery. Tech. Q. Master Brew. Assoc. Am. 48: 113-115.
Lentz MR, Stevens SM Jr, Raynes J, Elkhoury N. 2006. A phosphorylation map of the bovine papillomavirus E1 helicase. Virology Journal 3:13.
Lentz, M. R. 2002. A carboxyl-terminal serine of the bovine papillomavirus E1 protein is phosphorylated in vivo and in vitro. Virus Research 83: 213-219.
Lentz, M., Zanardi, T., Filzen, R., Carter, J., and Hella, M. 2002. Functional analysis of a carboxyl-terminal phosphorylation mutant of the BPV E1 protein. Journal of Molecular Biology 316: 597-607.