News and Events - Chemistry

 

NOTE: Prior to Fall 2016 seminars below refreshments
 will be served from 3 pm in 39/1003

 

October 21, 2016 
3.30 - 4.30 pm
Bldg 39/1003
Seminar: Dr. Christopher Dale (FIU)
October 7, 2016 
3.30 - 4.30 pm 
Bldg 39/1003
Seminar: "Transition metal catalysis with triazole-based metal complexes"Dr. Xiadong Shi (USF)
September 23, 2016 
3.30 - 4.30 pm 
Bldg 39/1003
Seminar: "Photon Upconversion Dye-Sensitized Solar Cells via Self-Assembled Bilayers on Nanocrystalline Metal Oxides" Dr. Kenneth Hanson (FSU)
September 9, 2016 
3.30 - 4.30 pm 
Bldg 39/1003
Seminar: "Developing Novel Tools and Methodologies for Studying Guanidinium Modifying Enzymes" Dr. Bryan Knuckley, UNF Department of Chemistry

The guanidinium modifying enzymes are a large class of enzymes that have been identified to play a significant role in a number of diseases, such as atherosclerosis, cancer, and multiple sclerosis.  The guanidinium modifying enzyme family includes the protein arginine methyltransferases (PRMTs) and the agmatine deiminases (AgDs), which have only recently become more attractive as drug targets.  However, the development of novel pharmaceuticals has been hindered by the lack of tools and methodologies that are currently available to study these enzymes.  To this end, we have successfully developed a novel screening methodology for evaluating the substrate specificity of the PRMT family of enzymes. This screen has resulted in the identification of PRMT-specific substrates, development of a new inhibitor, and a chemical probe to further study this enzyme family.  Furthermore, we have elucidated the catalytic mechanism of an agmatine deiminase found in Listeria monocytogenes, which is a major contributing factor to Listeriosis infection.  Listeriosis is an infection that can lead to miscarriages in pregnant women, meningitis in newborns, and death in immunocompromised individuals caused by consuming food contaminated with the bacteria, Listeria monocytogenes.  Also, these mechanistic studies have provided valuable information to designing chemical probes that target this family of enzymes.
September 2, 2016  Seminar: "Enhanced Lithography Through Chemistry" Dr. Thomas "TJ" Mullen, UNF Department of Chemistry

Complex surface structures with molecular-scale organization and chemical functionalities have garnered tremendous attention in recent years for applications including bioresponsive surfaces and lithographic resists.  Multicomponent alkanethiol-based chemical films assembled onto noble metal surfaces are commonly utilized due to their rich and well-characterized structures and chemistries. However, the patterning of these films is limited to two-dimensional features due to the reliance on the assembly of monomolecular films and the limited library of molecules available for patterning. We present two scanning probe lithographic strategies that are enhanced and extended by exploiting self- and directed molecular assembly.  The first strategy utilizes the sequential deposition of mercaptoalkanoic acid molecules and coordinated metal ions to create multilayer films where the overall film thickness of the multilayer film is governed by the number of iterations in the deposition process. We have combined this multilayer assembly strategy with nanoshaving to characterize and to manipulate the local structure of these multilayer films.  Nanoshaving utilizes an atomic force microscopy tip to displace adsorbed molecules from a surface to reveal the underlying Au substrate.  The second scanning probe lithographic strategy uses nanografting, which employs an atomic force microscopy tip to direct the assembly of molecules from solution, to pattern labile monolayers of 1-adamantanethiolate.  Once nanografting is complete, the 1-adamantanethiolate monolayers are displaced by molecules of interest via competitive desorption.  This methodology extends the types of surface structures that can be generated via nanografting and minimizes pattern dissolution by separating the patterning and molecular assembly processes.  By applying self- and directed assembly strategies in concert with molecules with distinctive properties, we can enhance and extend the precision, capabilities, and versatility of lithographic strategies.
July 1, 2016

Dr. Christos Lampropoulos has won an NSF-MRI grant as co-PI with Dr. Tom Pekarek (Physics). This is for an AC magnetic susceptibility measurement system for the SQUID magnetometer, and it is from the Division for Materials Research.

June 1, 2016 Dr. Stuart Chalk received a grant ($50K) from Springer Materials to extract chemical property data from PDF files that are volumes of the Landolt-Börnstein database.
April 5, 2016 Dr. Bryan Knuckley and Dr. Thomas "TJ" Mullen both received outstanding teaching awards for 2016
April 1, 2016 Dr's Lane, Causey, and Lampropoulos all receive tenure and promotion to Associate Professor