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TEACHING: General Biology, Genetics, Molecular and Cell Biology, Biology of Cancer, Senior Seminar. RESEARCH: Regulation of DNA Replication Accurate duplication of the genetic material, DNA, is a fundamental process for all living organisms. In my lab at UNF, we are investigating how this process is controlled in animal cells. We are using a virus as a model system for these studies. Papillomaviruses have a complex life cycle, including a stage when their DNA replication accurately reflects that of the infected cell. The viral DNA is well-characterized, simple to manipulate, and replicates in a predictable and observable way in laboratory cultured cells. We hypothesize that the host cell imposes regulation on the replication of viral DNA. We are using genetic and biochemical approaches to analyze control of replication of papillomavirus DNA. RECENT PUBLICATIONS Lentz MR, Stevens SM Jr, Raynes J, Elkhoury N. 2006. A phosphorylation map of the bovine papillomavirus E1 helicase. Virology Journal 3:13 Lentz, M. R. (2002) A carboxyl-terminal serine of the bovine papillomavirus E1 protein is phosphorylated in vivo and in vitro. Virus Research 83: 213-219. [ABSTRACT] Lentz, M., Zanardi, T., Filzen, R., Carter, J., and Hella, M. (2002) Functional analysis of a carboxyl-terminal phosphorylation mutant of the BPV E1 protein. Journal of Molecular Biology 316: 597-607. [ABSTRACT] Zanardi, T. A., Stanley, C. M., Saville, B. M., Spacek, S. M., and Lentz, M. R. (1997) Modulation of bovine papillomavirus DNA replication by phosphorylation of the viral E1 protein. Virology 228: 1-10. [ABSTRACT] Lentz, M. R., Pak, D., Mohr, I., and Botchan, M. R. (1993) The E1 replication protein of bovine papillomavirus type-1 contains an extended nuclear localization signal that includes a p34cdc2 phosphorylation site. J. Virol. 67: 1414-1423..[ABSTRACT |
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