Vladimir  Mashanov

Assistant Professor

Biology • College of Arts & Sciences

Areas of Expertise

Research interests: Regenerative Biology, Developmental Biology, Evolution of Neurogenesis

Teaching Responsibilities: Developmental Biology, Molecular and Cell Biology, General Biology 1

Education

Ph.D. (Developmental Biology, Embryology) A.V. Zhirmunsky Institute of Marine Biology, Vladivostok, Russia (2004)

B.S./M.S. (Cell and Developmental Biology) Far Eastern State University, Vladivostok, Russia (2001)

Biography

Research in my lab is driven by the following questions:

  • Why do some organisms readily regenerate injured or worn-out body parts, while others are not able to regenerate at all?
  • How did regenerative ability evolve in animal phylogeny and why was it lost in some animal groups?
  • What drives regeneration at the cellular and molecular levels and how much does regeneration share with other developmental phenomena, such as embryonic development, normal cell turnover, and cancer?

We address these questions using echinoderms as model organisms. The phylogenetic position of the phylum Echinodermata as an outgroup of chordates makes these marine invertebrates particularly attractive for regenerative research in the context of deuterostome evolution. The shared ancestry with humans opens up a possibility that better mechanistic understanding of echinoderm regeneration will inform the design of new therapeutic approaches to treat human injuries.

Awards

  • 2006-2008 Alexander von Humboldt Research Fellowship
  • 2008 A. V. Zhirmunsky Award (Far Eastern Branch of the Russian Academy of Sciences)
  • 2006-2007 Russian Science Support Foundation Fellowship
  • 2002 DAAD (Deutscher Akademischer Austauschdienst -- The German Academic Exchange Service) Fellowship for Young Scientists

Grants and Contracts Awarded

  • 2016 UNF Internal Technology Grant
  • 2013-2016 NSF IOS-1252679 (Co-PIs: J.E. Garcia-Arraras/V.S. Mashanov) "Plasticity of the echinoderm nervous system: cellular and molecular mechanisms of central nervous system regeneration"
  • 2005 President of Russia Grant for Young Scientist

Publications & Presentations

Peer-Reviewed Journal Articles:

 

Mashanov, V., Zueva, O., Mashanova, D., & Garcia-Arraras, J. E. (2017). Expression of  stem cell factors in the adult sea cucumber digestive tube. Cell Tissue Res, https://doi.org/10.1007/s00441-017-2692-y

 

Mashanov, V. S., Zueva, O. R., & Garcia-Arraras, J. E. (2017). Inhibition of cell proliferation does not slow down echinoderm neural regeneration. Front Zool 14(12). DOI: 10.1186/s12983-017-0196-y

 

Mashanov, V. S., Zueva, O. R., & Garcia-Arraras, J. E. (2015). Expression of pluripotency factors in echinoderm regeneration. Cell Tissue Res, 359(2), 521–536. doi:10.1007/s00441-014-2040-4

 

Mashanov, V. S., Zueva, O. R., & Garcia-Arraras, J. E. (2015). Heterogeneous generation of new cells in the adult echinoderm nervous system. Front. Neuroanat. (9), 123. doi:10.3389/fnana.2015.00123

 

Mashanov, V. S., Zueva, O. R., & Garcia-Arraras, J. E. (2015). Myc regulates programmed cell death and radial glia dedifferentiation after neural injury in an echinoderm. BMC Dev Biol, 15(1), 24. doi:10.1186/s12861-015-0071-z

 

Mashanov, V. S., Zueva, O. R., & Garcia-Arraras, J. E. (2014). Postembryonic organogenesis of the digestive tube: why does it occur in worms and sea cucumbers but fail in humans? Curr Top Dev Biol, 108, 185-216. doi:10.1016/B978-0-12-391498-9.00006-1

 

 

Mashanov, V. S., Zueva, O. R., & Garcia-Arraras, J. E. (2014). Transcriptomic changes during regeneration of the central nervous system in an echinoderm. BMC Genomics, 15(1), 357. doi:10.1186/1471-2164-15-357

 

 

Mashanov, V. S., Zueva, O. R., & Garcia-Arraras, J. E. (2013). Radial glial cells play a key role in echinoderm neural regeneration. BMC Biol, 11, 49. doi:10.1186/1741-7007-11-49

 

 

Mashanov, V. S., Zueva, O. R., & Garcia-Arraras, J. E. (2012). Expression of Wnt9, TCTP, and Bmp1/Tll in sea cucumber visceral regeneration. Gene Expr Patterns, 12(1-2), 24–35. doi:10.1016/j.gep.2011.10.003

 

 

Mashanov, V. S., Zueva, O. R., & Garcia-Arraras, J. E. (2012). Posttraumatic regeneration involves differential expression of long terminal repeat (LTR) retrotransposons. Dev Dyn, 241(10), 1625–1636. doi:10.1002/dvdy.23844

 

 

Mashanov, V. S., Zueva, O. R., & Garcia-Arraras, J. E. (2012). Retrotransposons in animal regeneration: overlooked components of the regenerative machinery? Mob Genet Elements, 2(5), 244–247. doi:10.4161/mge.22644

 

 

Mashanov, V. S. & Garcia-Arraras, J. E. (2011). Gut regeneration in holothurians: a snapshot of recent developments. Biol Bull, 221(1), 93–109

 

 

Mashanov, V. S., Zueva, O. R., & Garcia-Arraras, J. E. (2010). Organization of glial cells in the adult sea cucumber central nervous system. Glia, 58(13), 1581–1593. doi:10.1002/glia.21031

 

 

Mashanov, V. S., Zueva, O. R., Rojas-Catagena, C., & Garcia-Arraras, J. E. (2010). Visceral regeneration in a sea cucumber involves extensive expression of survivin and mortalin homologs in the mesothelium. BMC Dev Biol, 10, 117. doi:10.1186/1471-213X-10-117

 

 

Mashanov, V. S., Zueva, O. R., Heinzeller, T., Aschauer, B., Naumann, W. W., Grondona, J. M., Cifuentes, M., & Garcia-Arraras, J. E. (2009). The central nervous system of sea cucumbers (Echinodermata: Holothuroidea) shows positive immunostaining for a chordate glial secretion. Front Zool, 6, 11. doi:10.1186/1742-9994-6-11

 

Mashanov, V. S., Zueva, O. R., & Heinzeller, T. (2008). Regeneration of the radial nerve cord in a holothurian: a promising new model system for studying post-traumatic recovery in the adult nervous system. Tissue Cell, 40(5), 351–372. doi:10.1016/j.tice.2008.03.004

 

 

Dolmatov, I., Mashanov, V. S., & Zueva, O. R. (2007). Derivation of muscles of the Aristotle’s lantern from coelomic epithelia. Cell Tissue Res, 327(2), 371–384. doi:10.1007/s00441-006-0314-1

 

 

Mashanov, V. S., Charlina, N. A., Dolmatov, I. Y., & Wilkie, I. C. (2007). Juxtaligamental cells in the arm of the brittle star Amphipholis kochii Lütken, 1872 (Echinodermata: Ophiuroidea). Russian Journal of Marine Biology, 33, 110–117. doi:10.1134/S1063074007020058

 

 

Mashanov, V. S., Zueva, O. R., Heinzeller, T., Aschauer, B., & Dolmatov, I. Y. (2007). Developmental origin of the adult nervous system in a holothurian: an attempt to unravel the enigma of neurogenesis in echinoderms. Evol Dev, 9(3), 244–256. doi:10.1111/j.1525-142X.2007.00157.x

 

 

Mashanov, V. S., Zueva, O. R., Heinzeller, T., & Dolmatov, I. Y. (2006). Ultrastructure of the circumoral nerve ring and the radial nerve cords in holothurians (Echinodermata). Zoomorphology, 125(1), 27–38. doi:10.1007/s00435-005-0010-9

 

 

Mashanov, V. S., Dolmatov, I. Y., & Heinzeller, T. (2005). Transdifferentiation in holothurian gut regeneration. Biol Bull, 209(3), 184–193.

 

 

Odintsova, N. A., Dolmatov, I. Y., & Mashanov, V. S. (2005). Regenerating holothurian tissues as a source of cells for long-term cell cultures. Marine Biology, 146, 915–921.

 

 

Mashanov, V. S. & Dolmatov, I. (2004). Functional morphology of the developing alimentary canal in the holothurian Eupentacta fraudatrix (Holothuroidea, Dendrochirota). Acta Zoologica, 85(1), 29–39. doi:10.1111/j.0001-7272.2004.00155.x

 

 

Mashanov, V.S., Frolova, L. T., & Dolmatov, I. Y. (2004). Structure of the digestive tube in the holothurian Eupentacta fraudatrix (Holothuroidea: Dendrochirota). Russian Journal of Marine Biology, 30, 314–322.

 

 

Mashanov, V. S. & Dolmatov, I. (2001). Regeneration of the digestive tract in the pentactulae of the far-eastern holothurian Eupentacta fraudatrix (Holothuroidea, Dendrochirota). Invertebrate Reproduction and Development, 39, 143–151.

 

 

Mashanov, V. S. & Dolmatov, I. (2001). Ultrastructure of the alimentary canal in five-month-old pentactulae of the holothurian Eupentacta fraudatrix. Russian Journal of Marine Biology, 27, 320–328.

 

 

Mashanov, V. S. & Dolmatov, I. (2000). Developmental morphology of a holothurian, Cucumaria japonica (Dendrochirota, Holothuroidea), a species with accelerated metamorphosis. Invertebrate Reproduction and Development, 37, 137–146.

 

Books/Book Chapters:

 

Mashanov, V., Zueva, O., Rubilar, T., Epherra, L., and Garcia-Arraras, J. E. (2016) Echinodermata Chapter 51 In: Strcture and Evolution of Invertebrate Nervous Systems, Ed Schmidt-Raesa, A., Harszh, S., and Purschke, G. Oxford University Press

 

Dolmatov, I. & Mashanov, V. S. (2007). Regeneration in holothurians. Vladivostok: Dalnauka. (in Russian)

MashanovContact Information

Building 59, Room 2311

(904) 620-5629

vladimir.mashanov@unf.edu


Office Hours

MWF 8:30 - 9:30 am